Advances in Blood Substitutes: Industrial Opportunities and by Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim

By Robert M. Winslow M.D. (auth.), Robert M. Winslow M.D., Kim D. Vandegriff Ph.D., Marcos Intaglietta Ph.D. (eds.)

Each bankruptcy of this quantity is a contribution from knowledgeable within the box, selected by means of the editors to give a contribution to the 1997 "Current matters in Blood replacement learn and improvement" direction given in San Diego, March 17-19. The members have been chosen due to their services in components which the editors think to be serious to the development of the sector, and which replicate task in "hot" components of suitable examine. whereas there's a continuity well-liked for the yearly path, every year brings adjustments in emphasis and content material. In prior years, we have been frequently unable to supply time for individuals to offer their perspectives and critiques. therefore, this yr we inspired dialogue after every one presentation. those classes have been recorded, transcribed, and are published with the chapters herein. We think that the product is especially as regards to the taking pictures this year's path in print, and belief readers will get pleasure from analyzing the consistently candid and sometimes provocative comments from the viewers. the fee paid for inclusion of the dialogue transcriptions was once a hold up in book. each one writer used to be allowed to edit his/her dialogue part in addition to the ultimate model of the chapters sooner than ebook. The alterations are regularly for grammar, and we attempted, while attainable, to not modify the conversational sort of those interchanges.

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Extra info for Advances in Blood Substitutes: Industrial Opportunities and Medical Challenges

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So • • • •• e. 5 •• • . . • . • •• •• • . -....... - . • • . ,.. -" .. ~. 1 • ,. I.. 1. Blood velocity as a function of vessel diameter in normal pial vessels (top panel) and a human glioma (U87) xenograft on the pial surface (bottom panel). Note that in normal microcirculation, blood velocity is dependent on vessel diameter, whereas in tumors, there is no such dependence. Furthermore, the blood velocity in tumor vessels is about an order of magnitude lower than in host vessels (Adapted from Yuan et al.

J. Hosp. Pharm. 51: 210-218, 1994. , and C. Lister. A preclinical screening test for modified hemoglobin to bridge the gap between safety studies and use in humans. , Artif. Cells, ImmobiZ. Biotech. 20: 565-573, 1992. M. Schipper, and S. Brem. The prevention of oxyhemoglobin-induced endothelial and smooth muscle cytoskeletal injury by deferoxamine. Neurosurgery 32: 58-64, 1993. M. Chang. Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free-radicals and prevents methemoglobin formation and iron release.

Pharm. 51: 210-218, 1994. , and C. Lister. A preclinical screening test for modified hemoglobin to bridge the gap between safety studies and use in humans. , Artif. Cells, ImmobiZ. Biotech. 20: 565-573, 1992. M. Schipper, and S. Brem. The prevention of oxyhemoglobin-induced endothelial and smooth muscle cytoskeletal injury by deferoxamine. Neurosurgery 32: 58-64, 1993. M. Chang. Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free-radicals and prevents methemoglobin formation and iron release.

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