Advances in Cancer Research, Vol. 77 by George F. Vande Woude, George Klein

By George F. Vande Woude, George Klein

Advances in melanoma study presents worthy info at the fascinating and fast-moving box of melanoma study. the following once more, amazing and unique studies are provided. Key positive factors * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic worth * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability

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An extracellular portion, stabilized by two cysteine-rich domains (CRD-1 and CRD-2), possesses the ligand binding capacity of the receptor. Its four zones show a high diversity between the family members as presented in percentage of homology to the first identified receptor, ErbB-1. This diversity confers specific primary recognition of multiple ligands as listed for each of the receptors. Specificity is extended by cross-reactivity of several of the ligands; NRG1 and NRG2 are shared by ErbB-3 and ErbB-4; betacellulin, epiregulin, and HB-EGF are recognized by both ErbB-1 and ErbB-4.

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