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Advances in melanoma study presents worthy info at the fascinating and fast-moving box of melanoma study. the following once more, amazing and unique studies are provided. Key positive factors * The Yin Yang of TCF/b-Catenin Signalling * Biochemical and scientific Implications of the Erb/HER Signaling community of development issue Receptors * p53 and Human melanoma: the 1st 10000 Mutations * Macrophage Stimulating Protein * CD44 Glycoproteins in Colorectal melanoma; Expression; functionality; and Prognostic worth * an easy Modes for Carcinogenesis of Colorectal melanoma with Microsatellite Instability
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Extra resources for Advances in Cancer Research, Vol. 77
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An extracellular portion, stabilized by two cysteine-rich domains (CRD-1 and CRD-2), possesses the ligand binding capacity of the receptor. Its four zones show a high diversity between the family members as presented in percentage of homology to the ﬁrst identiﬁed receptor, ErbB-1. This diversity confers specific primary recognition of multiple ligands as listed for each of the receptors. Speciﬁcity is extended by cross-reactivity of several of the ligands; NRG1 and NRG2 are shared by ErbB-3 and ErbB-4; betacellulin, epiregulin, and HB-EGF are recognized by both ErbB-1 and ErbB-4.