Advances in Virus Research, Vol. 72 by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy

By Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy

Released in view that 1953, Advances in Virus examine covers a various variety of in-depth stories delivering a worthy evaluation of the present box of virology. The impression issue for 2006 is 3.48 putting it seventh within the hugely aggressive classification of virology. * Contributions from top professionals * Informs and updates on the entire most recent advancements within the box

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In essence, this feeding behavior overcompensates for Ae. aegypti’s limited oral susceptibility, which varies greatly in both Ae. albopictus and Ae. , 2001, 2003). The limited susceptibility of Ae. aegypti suggests that only DENV associated with high human viremia levels would be transmitted efficiently, thus selecting for viruses that generate high viremia titers. , 2003), mosquito infection may select for virulence of endemic DENV. Although the mechanism of maintenance of DENV during the dry season or during interepidemic periods has not been clearly elucidated, evidence suggests DENV maintenance by vertical (transovarial) transmission.

The available data suggest that the sylvatic strains are either confined to forest habitats and/or produce relatively mild illness (DEN fever). Most of our current understanding of human illness after infection with sylvatic DENV comes from the case histories of DENV infections in two Senegalese and three expatriate Caucasian patients, which led to the isolation and genetic characterization of DENV-2. , 1980). The second case involved a Caucasian scientist whose infection occurred while investigating the 1983 DENV amplification cycle in southeastern Senegal.

1999), ample opportunities for recombination are present. The possibility of DENV recombination may have significant epidemiological and clinical implications in endemic regions if licensure of the attenuated multivalent DENV candidate vaccines results in widespread human use. Overall, phylogenetic analyses indicated that the Southeast Asian endemic DENV serotypes evolved independently from progenitor sylvatic DENV in a series of convergence events after the establishment of sufficiently large urban populations in the Asia-Oceania region capable of supporting a human transmission cycle.

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